Research output per year
Research output per year
Personal profile
Research Interests
My research focuses on the mechanism of interaction of metal complexes with biomolecules that can lead to the formation of genetic aberrations such as mutations, cancer and toxicity. My primary metal of interest is chromium, which in the +6 oxidation state, is a known human carcinogen. One method by which chromium may induce cancer in humans is through oxidative damage to nucleic acids. Our research group is focused on the mechanism by which this oxidative chemistry may occur and the resulting lesions that are formed on DNA that can give rise to carcinogenesis.
Education/Academic qualification
Doctorate, Chemistry, Montana State University
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where Kent Sugden is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Base and nucleotide excision repair of oxidatively generated guanine lesions in DNA
Shafirovich, V., Kropachev, K., Anderson, T., Liu, Z., Kolbanovskiy, M., Martin, B. D., Sugden, K., Shim, Y., Chen, X., Min, J. H. & Geacintov, N. E., Mar 4 2016, In: Journal of Biological Chemistry. 291, 10, p. 5309-5319 11 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquats
Lacher, S. E., Gremaud, J. N., Skagen, K., Steed, E., Dalton, R., Sugden, K. D., Cardozo-Pelaez, F., Sherwin, C. M. T. & Woodahl, E. L., Feb 2014, In: Journal of Pharmacology and Experimental Therapeutics. 348, 2, p. 336-345 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Influence of substrate complexity on the diastereoselective formation of spiroiminodihydantoin and guanidinohydantoin from chromate oxidation
Gremaud, J. N., Martin, B. D. & Sugden, K. D., Feb 15 2010, In: Chemical Research in Toxicology. 23, 2, p. 379-385 7 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Chromium-Induced DNA Damage and Repair
Little, L. G. & Sugden, K. D., Apr 15 2009, Metal Complex-DNA Interactions. John Wiley & Sons, Ltd, p. 463-489 27 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
4 Scopus citations -
Inhibition by methylated organoarsenicals of the respiratory 2-oxo-acid dehydrogenases
Bergquist, E. R., Fischer, R. J., Sugden, K. D. & Martin, B. D., Mar 15 2009, In: Journal of Organometallic Chemistry. 694, 6, p. 973-980 8 p.Research output: Contribution to journal › Article › peer-review
96 Scopus citations