γ-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O-2 production

Andrij Holian, Michael A. Marchiarullo, Douglas F. Stickle

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of γ-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formyl-nle-leu-phe (FNLLP), 125μM HCC was found to stimulate PI cycle activity, calcium mobilization (45Ca2+ efflux and cytosolic [Ca2+] elevation) and O-2 production, although the action of HCC was prolonged in comparison. HCC treatment did not block subsequent stimulation by FNLLP. HCC is proposed to act at an early stage in the same activation sequence as does FNLLP.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalFEBS Letters
Volume176
Issue number1
DOIs
StatePublished - Oct 15 1984

Keywords

  • Calcium
  • Hexachlorocyclohexane
  • Macrophage
  • Phosphatidylinositol
  • Qu Formyl peptide

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