γ-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O-2 production

Andrij Holian; Michael A. Marchiarullo; Douglas F. Stickle

doi:10.1016/0014-5793(84)80930-8

γ-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O^-₂ production

Andrij Holian, Michael A. Marchiarullo, Douglas F. Stickle

University of Pennsylvania

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The influence of γ-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formyl-nle-leu-phe (FNLLP), 125μM HCC was found to stimulate PI cycle activity, calcium mobilization (⁴⁵Ca²⁺ efflux and cytosolic [Ca²⁺] elevation) and O^-₂ production, although the action of HCC was prolonged in comparison. HCC treatment did not block subsequent stimulation by FNLLP. HCC is proposed to act at an early stage in the same activation sequence as does FNLLP.

Original language	English
Pages (from-to)	151-154
Number of pages	4
Journal	FEBS Letters
Volume	176
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(84)80930-8
State	Published - Oct 15 1984

Keywords

Calcium
Hexachlorocyclohexane
Macrophage
Phosphatidylinositol
Qu Formyl peptide

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10.1016/0014-5793(84)80930-8

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title = "γ-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O-2 production",

abstract = "The influence of γ-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formyl-nle-leu-phe (FNLLP), 125μM HCC was found to stimulate PI cycle activity, calcium mobilization (45Ca2+ efflux and cytosolic [Ca2+] elevation) and O-2 production, although the action of HCC was prolonged in comparison. HCC treatment did not block subsequent stimulation by FNLLP. HCC is proposed to act at an early stage in the same activation sequence as does FNLLP.",

keywords = "Calcium, Hexachlorocyclohexane, Macrophage, Phosphatidylinositol, Qu Formyl peptide",

author = "Andrij Holian and Marchiarullo, {Michael A.} and Stickle, {Douglas F.}",

note = "Funding Information: This work was supportedb y grants HL-26266 and HL-28758f rom the National Heart, Lung and Blood Institute.",

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T1 - γ-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O-2 production

AU - Holian, Andrij

AU - Marchiarullo, Michael A.

AU - Stickle, Douglas F.

N1 - Funding Information: This work was supportedb y grants HL-26266 and HL-28758f rom the National Heart, Lung and Blood Institute.

PY - 1984/10/15

Y1 - 1984/10/15

N2 - The influence of γ-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formyl-nle-leu-phe (FNLLP), 125μM HCC was found to stimulate PI cycle activity, calcium mobilization (45Ca2+ efflux and cytosolic [Ca2+] elevation) and O-2 production, although the action of HCC was prolonged in comparison. HCC treatment did not block subsequent stimulation by FNLLP. HCC is proposed to act at an early stage in the same activation sequence as does FNLLP.

AB - The influence of γ-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formyl-nle-leu-phe (FNLLP), 125μM HCC was found to stimulate PI cycle activity, calcium mobilization (45Ca2+ efflux and cytosolic [Ca2+] elevation) and O-2 production, although the action of HCC was prolonged in comparison. HCC treatment did not block subsequent stimulation by FNLLP. HCC is proposed to act at an early stage in the same activation sequence as does FNLLP.

KW - Calcium

KW - Hexachlorocyclohexane

KW - Macrophage

KW - Phosphatidylinositol

KW - Qu Formyl peptide

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DO - 10.1016/0014-5793(84)80930-8

M3 - Article

C2 - 6208053

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SN - 0014-5793

VL - 176

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JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

γ-Hexachlorocyclohexane activation of alveolar macrophage phosphatidylinositol cycle, calcium mobilization and O^-₂ production

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Keywords

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