3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2- carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii

Todd M. Smith; Nigel D. Priestley; Andrew R. Knaggs; Tom Nguyen; Heinz G. Floss

doi:10.1039/C39930001612

3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2- carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii

Todd M. Smith, Nigel D. Priestley, Andrew R. Knaggs, Tom Nguyen, Heinz G. Floss

University of Washington

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Highly specific enzymes which activate 3,4-dimethylindole-2-carboxylate (DMI) and 4-(1-hydroxyethyl)quinoline-2-carboxylate (HEQ) to their acyl adenylates have been detected in cell-free extracts of the nosiheptide and thiostrepton producers, S. actuosus and S. Iaurentii, by an ATP/PP_i, exchange assay.

Original language	English
Pages (from-to)	1612-1614
Number of pages	3
Journal	Chemical Communications
Issue number	21
DOIs	https://doi.org/10.1039/C39930001612
State	Published - 1993

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title = "3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2- carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii",

abstract = "Highly specific enzymes which activate 3,4-dimethylindole-2-carboxylate (DMI) and 4-(1-hydroxyethyl)quinoline-2-carboxylate (HEQ) to their acyl adenylates have been detected in cell-free extracts of the nosiheptide and thiostrepton producers, S. actuosus and S. Iaurentii, by an ATP/PPi, exchange assay.",

author = "Smith, {Todd M.} and Priestley, {Nigel D.} and Knaggs, {Andrew R.} and Tom Nguyen and Floss, {Heinz G.}",

year = "1993",

doi = "10.1039/C39930001612",

language = "English",

pages = "1612--1614",

journal = "Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

number = "21",

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3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2- carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii. / Smith, Todd M.; Priestley, Nigel D.; Knaggs, Andrew R. et al.
In: Chemical Communications, No. 21, 1993, p. 1612-1614.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2- carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii

AU - Smith, Todd M.

AU - Priestley, Nigel D.

AU - Knaggs, Andrew R.

AU - Nguyen, Tom

AU - Floss, Heinz G.

PY - 1993

Y1 - 1993

N2 - Highly specific enzymes which activate 3,4-dimethylindole-2-carboxylate (DMI) and 4-(1-hydroxyethyl)quinoline-2-carboxylate (HEQ) to their acyl adenylates have been detected in cell-free extracts of the nosiheptide and thiostrepton producers, S. actuosus and S. Iaurentii, by an ATP/PPi, exchange assay.

AB - Highly specific enzymes which activate 3,4-dimethylindole-2-carboxylate (DMI) and 4-(1-hydroxyethyl)quinoline-2-carboxylate (HEQ) to their acyl adenylates have been detected in cell-free extracts of the nosiheptide and thiostrepton producers, S. actuosus and S. Iaurentii, by an ATP/PPi, exchange assay.

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DO - 10.1039/C39930001612

M3 - Article

AN - SCOPUS:0027495719

SN - 0022-4936

SP - 1612

EP - 1614

JO - Chemical Communications

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ER -

3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2- carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii

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