4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter

Victoria Hulubei, Scott B. Meikrantz, David A. Quincy, Tina Houle, John I. McKenna, Mark E. Rogers, Scott Steiger, N. R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, including the most active analog, 1k.

Original languageEnglish
Pages (from-to)6613-6620
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume20
Issue number22
DOIs
StatePublished - Nov 15 2012

Keywords

  • Adjuvant
  • Dihydropyridine
  • Isoxazole
  • Lateral metalation
  • Multidrug transporter

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