@article{3295d8452fba440a82af1c11fe96fb34,
title = "4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter",
abstract = "The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, including the most active analog, 1k.",
keywords = "Adjuvant, Dihydropyridine, Isoxazole, Lateral metalation, Multidrug transporter",
author = "Victoria Hulubei and Meikrantz, {Scott B.} and Quincy, {David A.} and Tina Houle and McKenna, {John I.} and Rogers, {Mark E.} and Scott Steiger and Natale, {N. R.}",
note = "Funding Information: MDR1 data was generously provided by the National Institute of Mental Health{\textquoteright}s Psychoactive Drug Screening Program (NIMH PDSP), Contract # HHSN-271-2008-00025-C (NIMH PDSP). The NIMH PDSP is Directed by Bryan L. Roth MD, PhD at the University of North Carolina at Chapel Hill and Project Officer Jamie Driscoll at NIMH, Bethesda MD, USA. Funding Information: The authors thank the NIH for grants GM42029, NS038444, and P20RR015583. ",
year = "2012",
month = nov,
day = "15",
doi = "10.1016/j.bmc.2012.09.022",
language = "English",
volume = "20",
pages = "6613--6620",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd",
number = "22",
}