A comprehensive study on the efficacy of a wearable sleep aid device featuring closed-loop real-time acoustic stimulation

Anh Nguyen, Galen Pogoncheff, Ban Xuan Dong, Nam Bui, Hoang Truong, Nhat Pham, Linh Nguyen, Hoang Nguyen-Huu, Khue Bui-Diem, Quan Vu-Tran-Thien, Sy Duong-Quy, Sangtae Ha, Tam Vu

Research output: Contribution to journalArticlepeer-review


Difficulty falling asleep is one of the typical insomnia symptoms. However, intervention therapies available nowadays, ranging from pharmaceutical to hi-tech tailored solutions, remain ineffective due to their lack of precise real-time sleep tracking, in-time feedback on the therapies, and an ability to keep people asleep during the night. This paper aims to enhance the efficacy of such an intervention by proposing a novel sleep aid system that can sense multiple physiological signals continuously and simultaneously control auditory stimulation to evoke appropriate brain responses for fast sleep promotion. The system, a lightweight, comfortable, and user-friendly headband, employs a comprehensive set of algorithms and dedicated own-designed audio stimuli. Compared to the gold-standard device in 883 sleep studies on 377 subjects, the proposed system achieves (1) a strong correlation (0.89 ± 0.03) between the physiological signals acquired by ours and those from the gold-standard PSG, (2) an 87.8% agreement on automatic sleep scoring with the consensus scored by sleep technicians, and (3) a successful non-pharmacological real-time stimulation to shorten the duration of sleep falling by 24.1 min. Conclusively, our solution exceeds existing ones in promoting fast falling asleep, tracking sleep state accurately, and achieving high social acceptance through a reliable large-scale evaluation.

Original languageEnglish
Article number17515
Pages (from-to)17515
JournalScientific Reports
Issue number1
StatePublished - Oct 16 2023


  • Acoustic Stimulation
  • Humans
  • Polysomnography
  • Sleep Initiation and Maintenance Disorders
  • Sleep/physiology
  • Wearable Electronic Devices


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