Abstract
Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomyces sp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT(2a) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
Original language | English |
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Pages (from-to) | 1097-1100 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 66 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2003 |