A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile

Andrea A. Stierle, Donald B. Stierle, Eric Goldstein, Keith Parker, Tim Bugni, Chad Baarson, Julie Gress, Danielle Blake

Research output: Contribution to journalArticlepeer-review

Abstract

Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomyces sp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT(2a) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.

Original languageEnglish
Pages (from-to)1097-1100
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number8
DOIs
StatePublished - Aug 1 2003

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