A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer

Paul M. Schneider, Mien Chie Hung, Robert S. Ames, Elizabeth A. Putnam, Blanetta Akpakip, Jack A. Roth

Research output: Contribution to journalArticlepeer-review

Abstract

We studied 60 patients with non-small cell lung cancer (NSCLC) for alterations in the epidermal growth factor receptor (EGFR) gene. 24 60 (40%) demonstrated cleavage of a 4.2 kb EcoRI fragment in the tumor DNA which was not observed in DNA from paired normal lung. This fragment corresponds to a genomic region that encodes for part of the intracellular tyrosine kinase domain of the EGFR. We demonstrated that an alteration is present which leads to an increased cleavage efficiency of restriction endonuclease EcoRI for a specific EcoRI site in this 4.2 kb fragment.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalLung Cancer
Volume6
Issue number3-4
DOIs
StatePublished - Oct 1990

Keywords

  • Epidermal growth factor receptor
  • Lung cancer

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