A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer

Paul M. Schneider; Mien Chie Hung; Robert S. Ames; Elizabeth A. Putnam; Blanetta Akpakip; Jack A. Roth

doi:10.1016/0169-5002(90)90109-Y

A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer

Paul M. Schneider
, Mien Chie Hung
, Robert S. Ames
, Elizabeth A. Putnam
, Blanetta Akpakip
, Jack A. Roth

Biomedical and Pharmaceutical Sciences

University of Texas Health Science Center at Houston

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We studied 60 patients with non-small cell lung cancer (NSCLC) for alterations in the epidermal growth factor receptor (EGFR) gene. 24 60 (40%) demonstrated cleavage of a 4.2 kb EcoRI fragment in the tumor DNA which was not observed in DNA from paired normal lung. This fragment corresponds to a genomic region that encodes for part of the intracellular tyrosine kinase domain of the EGFR. We demonstrated that an alteration is present which leads to an increased cleavage efficiency of restriction endonuclease EcoRI for a specific EcoRI site in this 4.2 kb fragment.

Original language	English
Pages (from-to)	65-72
Number of pages	8
Journal	Lung Cancer
Volume	6
Issue number	3-4
DOIs	https://doi.org/10.1016/0169-5002(90)90109-Y
State	Published - Oct 1990

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epidermal growth factor receptor
Lung cancer

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10.1016/0169-5002(90)90109-Y

Cite this

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title = "A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer",

abstract = "We studied 60 patients with non-small cell lung cancer (NSCLC) for alterations in the epidermal growth factor receptor (EGFR) gene. 24 60 (40\%) demonstrated cleavage of a 4.2 kb EcoRI fragment in the tumor DNA which was not observed in DNA from paired normal lung. This fragment corresponds to a genomic region that encodes for part of the intracellular tyrosine kinase domain of the EGFR. We demonstrated that an alteration is present which leads to an increased cleavage efficiency of restriction endonuclease EcoRI for a specific EcoRI site in this 4.2 kb fragment.",

keywords = "Epidermal growth factor receptor, Lung cancer",

author = "Schneider, \{Paul M.\} and Hung, \{Mien Chie\} and Ames, \{Robert S.\} and Putnam, \{Elizabeth A.\} and Blanetta Akpakip and Roth, \{Jack A.\}",

year = "1990",

month = oct,

doi = "10.1016/0169-5002(90)90109-Y",

language = "English",

volume = "6",

pages = "65--72",

journal = "Lung Cancer",

issn = "0169-5002",

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T1 - A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer

AU - Schneider, Paul M.

AU - Hung, Mien Chie

AU - Ames, Robert S.

AU - Putnam, Elizabeth A.

AU - Akpakip, Blanetta

AU - Roth, Jack A.

PY - 1990/10

Y1 - 1990/10

N2 - We studied 60 patients with non-small cell lung cancer (NSCLC) for alterations in the epidermal growth factor receptor (EGFR) gene. 24 60 (40%) demonstrated cleavage of a 4.2 kb EcoRI fragment in the tumor DNA which was not observed in DNA from paired normal lung. This fragment corresponds to a genomic region that encodes for part of the intracellular tyrosine kinase domain of the EGFR. We demonstrated that an alteration is present which leads to an increased cleavage efficiency of restriction endonuclease EcoRI for a specific EcoRI site in this 4.2 kb fragment.

AB - We studied 60 patients with non-small cell lung cancer (NSCLC) for alterations in the epidermal growth factor receptor (EGFR) gene. 24 60 (40%) demonstrated cleavage of a 4.2 kb EcoRI fragment in the tumor DNA which was not observed in DNA from paired normal lung. This fragment corresponds to a genomic region that encodes for part of the intracellular tyrosine kinase domain of the EGFR. We demonstrated that an alteration is present which leads to an increased cleavage efficiency of restriction endonuclease EcoRI for a specific EcoRI site in this 4.2 kb fragment.

KW - Epidermal growth factor receptor

KW - Lung cancer

UR - https://www.scopus.com/pages/publications/0025222233

U2 - 10.1016/0169-5002(90)90109-Y

DO - 10.1016/0169-5002(90)90109-Y

M3 - Article

AN - SCOPUS:0025222233

SN - 0169-5002

VL - 6

SP - 65

EP - 72

JO - Lung Cancer

JF - Lung Cancer

IS - 3-4

ER -

A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer

Abstract

UN SDGs

Keywords

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