Acute differences in blood lipids and inflammatory biomarkers following controlled exposures to cookstove air pollution in the STOVES study

Ethan S. Walker, Kristen M. Fedak, Nicholas Good, John Balmes, Robert D. Brook, Maggie L. Clark, Tom Cole-Hunter, Robert B. Devlin, Christian L’Orange, Gary Luckasen, John Mehaffy, Rhiannon Shelton, Ander Wilson, John Volckens, Jennifer L. Peel

Research output: Contribution to journalArticlepeer-review

Abstract

Household air pollution is a leading risk factor for morbidity and premature mortality. Numerous cookstoves have been developed to reduce household air pollution, but it is unclear whether such cookstoves meaningfully improve health. In a controlled exposure study with a crossover design, we assessed the effect of pollution emitted from multiple cookstoves on acute differences in blood lipids and inflammatory biomarkers. Participants (n = 48) were assigned to treatment sequences of exposure to air pollution emitted from five cookstoves and a filtered-air control. Blood lipids and inflammatory biomarkers were measured before and 0, 3, and 24 hours after treatments. Many of the measured outcomes had inconsistent results. However, compared to control, intercellular adhesion molecule-1 was higher 3 hours after all treatments, and C-reactive protein and serum amyloid-A were higher 24 hours after the highest treatment. Our results suggest that short-term exposure to cookstove air pollution can increase inflammatory biomarkers within 24 hours.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalInternational Journal of Environmental Health Research
DOIs
StatePublished - 2020

Keywords

  • Air pollution
  • biomass burning
  • inflammation
  • lipoproteins

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