Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study

Erin O. Semmens, Cindy S. Leary, Annette L. Fitzpatrick, Sindana D. Ilango, Christina Park, Claire E. Adam, Steven T. DeKosky, Oscar Lopez, Anjum Hajat, Joel D. Kaufman

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Growing evidence implicates air pollution as a risk factor for dementia, but prior work is limited by challenges in diagnostic accuracy and assessing exposures in the decades prior to disease development. We evaluated the impact of long-term fine particulate matter (PM2.5) exposures on incident dementia (all-cause, Alzheimer's disease [AD], and vascular dementia [VaD]) in older adults. Methods: A panel of neurologists adjudicated dementia cases based on extensive neuropsychological testing and magnetic resonance imaging. We applied validated fine-scale air pollutant models to reconstructed residential histories to assess exposures. Results: An interquartile range increase in 20-year PM2.5 was associated with a 20% higher risk of dementia (95% confidence interval [CI]: 5%, 37%) and an increased risk of mixed VaD/AD but not AD alone. Discussion: Our findings suggest that air pollutant exposures over decades contribute to dementia and that effects of current exposures may be experienced years into the future.

Original languageEnglish
Pages (from-to)549-559
Number of pages11
JournalAlzheimer's and Dementia
Volume19
Issue number2
DOIs
StatePublished - Feb 2023

Keywords

  • Alzheimer's disease
  • air pollution
  • dementia
  • longitudinal cohort study
  • vascular dementia
  • Humans
  • Alzheimer Disease/epidemiology
  • Dementia, Vascular/epidemiology
  • Air Pollution/adverse effects
  • Ginkgo biloba
  • Air Pollutants/adverse effects
  • Particulate Matter/adverse effects
  • Aged

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