TY - JOUR
T1 - Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials
AU - Calderón-Garcidueñas, Lilian
AU - D'Angiulli, Amedeo
AU - Kulesza, Randy J.
AU - Torres-Jardón, Ricardo
AU - Osnaya, Norma
AU - Romero, Lina
AU - Keefe, Sheyla
AU - Herritt, Lou
AU - Brooks, Diane M.
AU - Avila-Ramirez, Jose
AU - Delgado-Chávez, Ricardo
AU - Medina-Cortina, Humberto
AU - González-González, Luis Oscar
PY - 2011/6
Y1 - 2011/6
N2 - We assessed brainstem inflammation in children exposed to air pollutants by comparing brainstem auditory evoked potentials (BAEPs) and blood inflammatory markers in children age 96.3±8.5 months from highly polluted (n=34) versus a low polluted city (n=17). The brainstems of nine children with accidental deaths were also examined. Children from the highly polluted environment had significant delays in wave III (t(50)=17.038; p<0.0001) and wave V (t(50)=19.730; p<0.0001) but no delay in wave I (p=0.548). They also had significantly longer latencies than controls for interwave intervals I-III, III-V, and I-V (all t(50)>7.501; p<0.0001), consisting with delayed central conduction time of brainstem neural transmission. Highly exposed children showed significant evidence of inflammatory markers and their auditory and vestibular nuclei accumulated α synuclein and/or β amyloid1-42. Medial superior olive neurons, critically involved in BAEPs, displayed significant pathology. Children's exposure to urban air pollution increases their risk for auditory and vestibular impairment.
AB - We assessed brainstem inflammation in children exposed to air pollutants by comparing brainstem auditory evoked potentials (BAEPs) and blood inflammatory markers in children age 96.3±8.5 months from highly polluted (n=34) versus a low polluted city (n=17). The brainstems of nine children with accidental deaths were also examined. Children from the highly polluted environment had significant delays in wave III (t(50)=17.038; p<0.0001) and wave V (t(50)=19.730; p<0.0001) but no delay in wave I (p=0.548). They also had significantly longer latencies than controls for interwave intervals I-III, III-V, and I-V (all t(50)>7.501; p<0.0001), consisting with delayed central conduction time of brainstem neural transmission. Highly exposed children showed significant evidence of inflammatory markers and their auditory and vestibular nuclei accumulated α synuclein and/or β amyloid1-42. Medial superior olive neurons, critically involved in BAEPs, displayed significant pathology. Children's exposure to urban air pollution increases their risk for auditory and vestibular impairment.
KW - Air pollution
KW - Alpha synuclein
KW - Auditory nuclei
KW - Beta amyloid
KW - Brainstem evoked auditory potentials
KW - Brainstem inflammation
KW - Children
KW - Neuroinflammation
UR - http://www.scopus.com/inward/record.url?scp=79955786502&partnerID=8YFLogxK
U2 - 10.1016/j.ijdevneu.2011.03.007
DO - 10.1016/j.ijdevneu.2011.03.007
M3 - Article
C2 - 21458557
AN - SCOPUS:79955786502
SN - 0736-5748
VL - 29
SP - 365
EP - 375
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
IS - 4
ER -
