Abstract
An Asymmetric isoxazole annulation proceeds from the (S)‐O‐methoxyphenylalaninol imine of (RS)‐2‐phen‐ylpropionaldehyde (3). Deprotonation, quenching with 4‐chloromethyl‐3,5‐dimethylisoxazole, and hydrolysis produced isoxazolylaldehyde (5), whose structure was confirmed by single crystal X‐ray diffractometry. The absolute configuration of (‐)‐5 was established as (R)‐by chemical correlation to the known (S)‐(‐)‐4‐methyl‐4‐phenyl‐cyclohex‐2‐ene‐1‐one (7).
| Original language | English |
|---|---|
| Pages (from-to) | 1067-1070 |
| Number of pages | 4 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1988 |