Abstract
Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2′-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.
Original language | English |
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Pages (from-to) | 239-244 |
Number of pages | 6 |
Journal | Mutation Research Letters |
Volume | 244 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1990 |
Keywords
- Chromium
- Oxygen dependence