An oxygen dependence in chromium mutagenesis

Kent D. Sugden; Robert B. Burris; Samuel J. Rogers

doi:10.1016/0165-7992(90)90135-7

An oxygen dependence in chromium mutagenesis

Kent D. Sugden, Robert B. Burris, Samuel J. Rogers

Chemistry and Biochemistry

Montana State University

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2′-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.

Original language	English
Pages (from-to)	239-244
Number of pages	6
Journal	Mutation Research Letters
Volume	244
Issue number	3
DOIs	https://doi.org/10.1016/0165-7992(90)90135-7
State	Published - Jul 1990

Keywords

Chromium
Oxygen dependence

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10.1016/0165-7992(90)90135-7

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title = "An oxygen dependence in chromium mutagenesis",

abstract = "Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2′-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.",

keywords = "Chromium, Oxygen dependence",

author = "Sugden, \{Kent D.\} and Burris, \{Robert B.\} and Rogers, \{Samuel J.\}",

year = "1990",

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journal = "Mutation Research Letters",

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T1 - An oxygen dependence in chromium mutagenesis

AU - Sugden, Kent D.

AU - Burris, Robert B.

AU - Rogers, Samuel J.

PY - 1990/7

Y1 - 1990/7

N2 - Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2′-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.

AB - Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2′-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.

KW - Chromium

KW - Oxygen dependence

UR - https://www.scopus.com/pages/publications/0025331495

U2 - 10.1016/0165-7992(90)90135-7

DO - 10.1016/0165-7992(90)90135-7

M3 - Article

C2 - 2195337

AN - SCOPUS:0025331495

SN - 0165-7992

VL - 244

SP - 239

EP - 244

JO - Mutation Research Letters

JF - Mutation Research Letters

IS - 3

ER -

An oxygen dependence in chromium mutagenesis

Abstract

Keywords

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