Asymptotic analysis of a complex reaction scheme in solid-liquid system

Heikki Haario, Leonid Kalachev

Research output: Contribution to journalArticlepeer-review


Asymptotic analysis of a complex reaction, Claisen condensation, is discussed. Under certain assumptions related to experimental observations the kinetics scheme of the reaction can be considerably reduced. Additional complications in the problem arise due to the fact that one of the substances is present in a sparingly soluble solid phase. We show how reductions for increasingly complex systems with kinetics, mass transfer and feed can be systematically handled by employing the methodology of asymptotic analysis. Generalizations of the reduction approach for the case of an arbitrary number of fast intermediate reactions are also considered. The identification of model parameters is considered with aid of the reduced systems. Questions of parameter estimation and optimal design of experiments are discussed using the MCMC methods.

Original languageEnglish
Pages (from-to)2823-2834
Number of pages12
JournalChemical Engineering Science
Issue number13
StatePublished - Jul 2003


  • Asymptotic analysis
  • Dissolution
  • Kinetics
  • Mass transfer
  • Model reduction
  • Parameter identification


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