Azaphilones from an Acid Mine Extremophile Strain of a Pleurostomophora sp.

Andrea A. Stierle, Donald B. Stierle, Teri Girtsman, T. C. Mou, Christophe Antczak, Hakim Djaballah

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

An extremophilic fungus identified as a Pleurostomophora sp. was isolated from the Berkeley Pit, an acid mine waste lake. When grown in liquid culture, the fungus produced berkchaetoazaphilones A-C (1, 2, and 5), the red pigment berkchaetorubramine (6), and the known compound 4-(hydroxymethyl)quinoline. These compounds were evaluated as inhibitors of matrix metalloproteinase-3, caspase-1, and proinflammatory cytokine production in induced THP-1 cells. Berkchaetoazaphilone B (2) inhibited IL-1β, TNFα, and IL-6 production in the induced inflammasome assay and was cytotoxic toward human retinoblastoma cell line Y79 (IC50 = 1.1 μM), leukemia cell lines CCRF-CEM and SR, and the melanoma cell line LOX IMVI (IC50 = 10 μM).

Original languageEnglish
Pages (from-to)2917-2923
Number of pages7
JournalJournal of Natural Products
Volume78
Issue number12
DOIs
StatePublished - Dec 24 2015

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