TY - JOUR
T1 - Bacteriophage-Bacteria Interactions in the Gut
T2 - From Invertebrates to Mammals
AU - Kirsch, Joshua M.
AU - Brzozowski, Robert S.
AU - Faith, Dominick
AU - Round, June L.
AU - Secor, Patrick R.
AU - Duerkop, Breck A.
N1 - Publisher Copyright:
© 2021 Annual Reviews Inc.. All rights reserved.
PY - 2021/9/29
Y1 - 2021/9/29
N2 - Bacteria and their viruses (bacteriophages or phages) interact antagonistically and beneficially in polymicrobial communities such as the guts of animals. These interactions are multifaceted and are influenced by environmental conditions. In this review, we discuss phage-bacteria interactions as they relate to the complex environment of the gut. Within the mammalian and invertebrate guts, phages and bacteria engage in diverse interactions including genetic coexistence through lysogeny, and phages directly modulate microbiota composition and the immune system with consequences that are becoming recognized as potential drivers of health and disease. With greater depth of understanding of phage-bacteria interactions in the gut and the outcomes, future phage therapies become possible.
AB - Bacteria and their viruses (bacteriophages or phages) interact antagonistically and beneficially in polymicrobial communities such as the guts of animals. These interactions are multifaceted and are influenced by environmental conditions. In this review, we discuss phage-bacteria interactions as they relate to the complex environment of the gut. Within the mammalian and invertebrate guts, phages and bacteria engage in diverse interactions including genetic coexistence through lysogeny, and phages directly modulate microbiota composition and the immune system with consequences that are becoming recognized as potential drivers of health and disease. With greater depth of understanding of phage-bacteria interactions in the gut and the outcomes, future phage therapies become possible.
UR - http://www.scopus.com/inward/record.url?scp=85116430380&partnerID=8YFLogxK
U2 - 10.1146/annurev-virology-091919-101238
DO - 10.1146/annurev-virology-091919-101238
M3 - Review article
C2 - 34255542
AN - SCOPUS:85116430380
SN - 2327-056X
VL - 8
SP - 95
EP - 113
JO - Annual Review of Virology
JF - Annual Review of Virology
ER -