Historically, a number of bacteriophage-like particles have been observed in association with members of the bacterial order Spirochetales, the spirochetes. In the last decade, several spirochete bacteriophages have been isolated and characterized at the molecular level. We have recently characterized a bacteriophage of the Lyme disease agent, Borrelia burgdorferi, which we have designated φBB-1. Here we review the history of the association between the spirochetes and their bacteriophages, with a particular emphasis on φBB-1 and its prophage, the 32-kb circular plasmid family of B. burgdorferi.
|Number of pages
|Journal of Molecular Microbiology and Biotechnology
|Published - 2000