Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism

Donald B. Stierle, Andrea A. Stierle, J. David Hobbs, Janalee Stokken, Jon Clardy

Research output: Contribution to journalArticlepeer-review

Abstract

(Equation presented) Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.

Original languageEnglish
Pages (from-to)1049-1052
Number of pages4
JournalOrganic Letters
Volume6
Issue number6
DOIs
StatePublished - Mar 18 2004

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