Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism

Donald B. Stierle; Andrea A. Stierle; J. David Hobbs; Janalee Stokken; Jon Clardy

doi:10.1021/ol049852k

Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism

Donald B. Stierle, Andrea A. Stierle, J. David Hobbs, Janalee Stokken, Jon Clardy

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Abstract

(Equation presented) Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.

Original language	English
Pages (from-to)	1049-1052
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/ol049852k
State	Published - Mar 18 2004

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10.1021/ol049852k

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title = "Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism",

abstract = "(Equation presented) Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.",

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year = "2004",

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doi = "10.1021/ol049852k",

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T1 - Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism

AU - Stierle, Donald B.

AU - Stierle, Andrea A.

AU - Hobbs, J. David

AU - Stokken, Janalee

AU - Clardy, Jon

PY - 2004/3/18

Y1 - 2004/3/18

N2 - (Equation presented) Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.

AB - (Equation presented) Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.

UR - https://www.scopus.com/pages/publications/1642568806

U2 - 10.1021/ol049852k

DO - 10.1021/ol049852k

M3 - Article

C2 - 15012097

AN - SCOPUS:1642568806

SN - 1523-7060

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SP - 1049

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JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism

Abstract

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