@article{ac54a172c2704ce68559dee9b23b6c3b,
title = "Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism",
abstract = "(Equation presented) Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.",
author = "Stierle, \{Donald B.\} and Stierle, \{Andrea A.\} and Hobbs, \{J. David\} and Janalee Stokken and Jon Clardy",
year = "2004",
month = mar,
day = "18",
doi = "10.1021/ol049852k",
language = "English",
volume = "6",
pages = "1049--1052",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "6",
}
