Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes

Donald B. Stierle, Andrea A. Stierle, Brianna Patacini, Kyle McIntyre, Teri Girtsman, Erin Bolstad

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72 Scopus citations

Abstract

The Berkeley Pit, an acid mine waste lake, is a source of extremophilic microorganisms that produce interesting bioactive compounds. We have previously reported the isolation of berkeleydione (1), berkeleytrione (2), the berkeleyacetals, and the berkeleyamides from the Pit Lake fungus Penicillium rubrum. In this paper we report the isolation and characterization of berkeleyones -C (4, 5, and 7) as well as previously described preaustinoid A (3) and A1(6) from this same fungus. These compounds were evaluated as inhibitors of the signaling enzyme caspase-1 and as potential inhibitors of interleukin 1-β production by inflammasomes in induced THP-1 cell line assays.

Original languageEnglish
Pages (from-to)2273-2277
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number10
DOIs
StatePublished - Oct 28 2011

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