Abstract
Berkeley Pit Lake is an abandoned open-pit copper mine filled with 30 billion gallons of acidic, metal-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive metabolites. Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of the novel spiroketal, berkelic acid 1, and of the known γ-pyrone, spiciferone A 4. Berkelic acid has shown selective, nanomolar activity against OVCAR-3, an ovarian cancer cell line in the National Cancer Institute cell line screen. The isolation and characterization of these compounds are reported here.
Original language | English |
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Pages (from-to) | 5357-5360 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 71 |
Issue number | 14 |
DOIs | |
State | Published - Jul 7 2006 |