Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity

Mariusz P. Gajewski; Howard Beall; Mark Schnieder; Sarah M. Stranahan; Michael D. Mosher; Kevin C. Rider; Nicholas R. Natale

doi:10.1016/j.bmcl.2009.06.019

Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity

Mariusz P. Gajewski, Howard Beall, Mark Schnieder, Sarah M. Stranahan, Michael D. Mosher, Kevin C. Rider, Nicholas R. Natale

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.

Original language	English
Pages (from-to)	4067-4069
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.019
State	Published - Aug 1 2009

Funding

The authors are grateful to the National Institutes of Health for NINDS 7R15-NS038444-04 and P20 RR015583. We thank Dr. J. B. A. (Sandy) Ross, director of the BioSpectroscopy Core at the Center for Structural and Functional Neuroscience, University of Montana, and Ayesha Sharmin for their assistance with fluorescence spectroscopy, funded by P20 RR015583. S.M.S. acknowledges summer research support from NSF REU CHE 0243760, while N.R.N. was at the University of Idaho. K.C.R. thanks P30 NS055022. We would like to thank Dr. Keith Taylor for helpful discussions on the implementation of Symyx Draw. We thank ChemAxon for use of their software. We also acknowledge Dr. David J. Burkhart of GSKBio for the use of their NMR.

Funder number
REU CHE 0243760, P30 NS055022
R15NS038444

Keywords

Anthracene
Antitumor
Fluorescence
G-quadruplex DNA
Glioma
Isoxazole
SNB-19

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10.1016/j.bmcl.2009.06.019

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title = "Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity",

abstract = "Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.",

keywords = "Anthracene, Antitumor, Fluorescence, G-quadruplex DNA, Glioma, Isoxazole, SNB-19",

author = "Gajewski, \{Mariusz P.\} and Howard Beall and Mark Schnieder and Stranahan, \{Sarah M.\} and Mosher, \{Michael D.\} and Rider, \{Kevin C.\} and Natale, \{Nicholas R.\}",

note = "Funding Information: The authors are grateful to the National Institutes of Health for NINDS 7R15-NS038444-04 and P20 RR015583. We thank Dr. J. B. A. (Sandy) Ross, director of the BioSpectroscopy Core at the Center for Structural and Functional Neuroscience, University of Montana, and Ayesha Sharmin for their assistance with fluorescence spectroscopy, funded by P20 RR015583. S.M.S. acknowledges summer research support from NSF REU CHE 0243760, while N.R.N. was at the University of Idaho. K.C.R. thanks P30 NS055022. We would like to thank Dr. Keith Taylor for helpful discussions on the implementation of Symyx Draw. We thank ChemAxon for use of their software. We also acknowledge Dr. David J. Burkhart of GSKBio for the use of their NMR. ",

year = "2009",

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doi = "10.1016/j.bmcl.2009.06.019",

language = "English",

volume = "19",

pages = "4067--4069",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity

AU - Gajewski, Mariusz P.

AU - Beall, Howard

AU - Schnieder, Mark

AU - Stranahan, Sarah M.

AU - Mosher, Michael D.

AU - Rider, Kevin C.

AU - Natale, Nicholas R.

N1 - Funding Information: The authors are grateful to the National Institutes of Health for NINDS 7R15-NS038444-04 and P20 RR015583. We thank Dr. J. B. A. (Sandy) Ross, director of the BioSpectroscopy Core at the Center for Structural and Functional Neuroscience, University of Montana, and Ayesha Sharmin for their assistance with fluorescence spectroscopy, funded by P20 RR015583. S.M.S. acknowledges summer research support from NSF REU CHE 0243760, while N.R.N. was at the University of Idaho. K.C.R. thanks P30 NS055022. We would like to thank Dr. Keith Taylor for helpful discussions on the implementation of Symyx Draw. We thank ChemAxon for use of their software. We also acknowledge Dr. David J. Burkhart of GSKBio for the use of their NMR.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.

AB - Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.

KW - Anthracene

KW - Antitumor

KW - Fluorescence

KW - G-quadruplex DNA

KW - Glioma

KW - Isoxazole

KW - SNB-19

UR - https://www.scopus.com/pages/publications/67649990310

U2 - 10.1016/j.bmcl.2009.06.019

DO - 10.1016/j.bmcl.2009.06.019

M3 - Article

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AN - SCOPUS:67649990310

SN - 0960-894X

VL - 19

SP - 4067

EP - 4069

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity

Abstract

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Keywords

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