Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation

Nicholas J. Day, Mary Ellenbecker, Ekaterina Voronina

Research output: Contribution to journalArticlepeer-review

Abstract

Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here, we use a genomic approach to identify transcripts associated with DLC-1, a protein previously identified as a cofactor of two unrelated RNA-binding proteins that act in the Caenorhabditis elegans germline. Among the 2732 potential DLC-1 targets, most are germline mRNAs associated with oogenesis. Removal of DLC-1 affects expression of its targets expressed in the oocytes, meg-1 and meg-3. We propose that DLC-1 acts as a cofactor for multiple ribonucleoprotein complexes, including the ones regulating gene expression during oogenesis.

Original languageEnglish
Pages (from-to)3683-3695
Number of pages13
JournalFEBS Letters
Volume592
Issue number22
DOIs
StatePublished - Nov 2018

Keywords

  • LC8
  • RNA-binding protein
  • germline
  • oogenesis

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