Calculation of hydrodynamic parameters: US-SOMO

Emre Brookes, Mattia Rocco

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Although it now offers a number of complementary applications for data processing and multiresolution modeling of (bio)macromolecules in solution, the UltraScan SOlution MOdeler (US-SOMO) suite of programs was initially developed for the computation of their solution properties starting from atomicresolution structures and their comparison with experimental data. In this chapter, we will give a brief overview of the basic principles behind the hydrodynamic parameter computational methods available in US-SOMO and outline their operation.

Original languageEnglish
Title of host publicationAnalytical Ultracentrifugation
Subtitle of host publicationInstrumentation, Software, and Applications
PublisherSpringer Japan
Number of pages25
ISBN (Electronic)9784431559856
ISBN (Print)9784431559832
StatePublished - Jan 1 2016


  • Bead modeling
  • Diffusion coefficient
  • Intrinsic viscosity
  • Multiresolution modeling
  • Sedimentation coefficient
  • Solution structure


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