Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum

Donald B. Stierle; Andrea A. Stierle; Teri Girtsman; Kyle McIntyre; Jesse Nichols

doi:10.1021/np200528n

Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum

Donald B. Stierle, Andrea A. Stierle, Teri Girtsman, Kyle McIntyre, Jesse Nichols

University of Montana

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.

Original language	English
Pages (from-to)	262-266
Number of pages	5
Journal	Journal of Natural Products
Volume	75
Issue number	2
DOIs	https://doi.org/10.1021/np200528n
State	Published - Feb 24 2012

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abstract = "Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.",

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AU - Stierle, Donald B.

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AU - Girtsman, Teri

AU - McIntyre, Kyle

AU - Nichols, Jesse

PY - 2012/2/24

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AB - Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.

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Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum

Abstract

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