Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum

Donald B. Stierle, Andrea A. Stierle, Teri Girtsman, Kyle McIntyre, Jesse Nichols

Research output: Contribution to journalArticlepeer-review

Abstract

Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalJournal of Natural Products
Volume75
Issue number2
DOIs
StatePublished - Feb 24 2012

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