Catalytic asymmetric synthesis of glutamate analogues

David J. Burkhart, Andrew R. McKenzie, Jared K. Nelson, Katherine I. Myers, Xue Zhao, Kathy R. Magnusson, Nicholas R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral centers α or β at the C-5 position do not detract from diastereoselectivity of the Jacobsen-Strecker reaction.

Original languageEnglish
Pages (from-to)1285-1288
Number of pages4
JournalOrganic Letters
Volume6
Issue number8
DOIs
StatePublished - Apr 15 2004

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