Cav3.2 T-type calcium channels control acute itch in mice

Vinicius M. Gadotti, Joanna M. Kreitinger, Nicholas B. Wageling, Dylan Budke, Philippe Diaz, Gerald W. Zamponi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Cav3.2 T-type calcium channels are important mediators of nociceptive signaling, but their roles in the transmission of itch remains poorly understood. Here we report a key involvement of these channels as key modulators of itch/pruritus-related behavior. We compared scratching behavior responses between wild type and Cav3.2 null mice in models of histamine- or chloroquine-induced itch. We also evaluated the effect of the T-type calcium channel blocker DX332 in male and female wild-type mice injected with either histamine or chloroquine. Cav3.2 null mice exhibited decreased scratching responses during both histamine- and chloroquine-induced acute itch. DX332 co-injected with the pruritogens inhibited scratching responses of male and female mice treated with either histamine or chloroquine. Altogether, our data provide strong evidence that Cav3.2 T-type channels exert an important role in modulating histamine-dependent and -independent itch transmission in the primary sensory afferent pathway, and highlight these channels as potential pharmacological targets to treat pruritus.

Original languageEnglish
Article number119
JournalMolecular Brain
Issue number1
StatePublished - Sep 1 2020


  • Cav3.2 T-type channel
  • Chloroquine
  • Histamine
  • Itch
  • Pruritus


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