TY - JOUR
T1 - C/D box snoRNAs in viral infections
T2 - RNA viruses use old dogs for new tricks
AU - Stamm, Stefan
AU - Lodmell, J. Stephen
N1 - Publisher Copyright:
© 2019
PY - 2019/6
Y1 - 2019/6
N2 - C/D box snoRNAs (SNORDs)are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate pre-mRNA splicing and polyadenylation of numerous genes. There is an emerging body of evidence for functional interactions between RNA viruses and C/D box snoRNAs. The infectivity of some RNA viruses depends on enzymatically active fibrillarin, and many RNA viral proteins associate with nucleolin or nucleophosmin, suggesting that viruses benefit from their cytosolic accumulation. These interactions are likely reflected by morphological changes in the nucleolus, often leading to relocalization of nucleolar proteins and ncRNAs to the cytosol that are a characteristic feature of viral infections. Knock-down studies have also shown that RNA viruses need specific C/D box snoRNAs for optimal replication, suggesting that RNA viruses benefit from gene expression programs regulated by SNORDs, or that viruses have evolved “new” uses for these humble ncRNAs to advance their prospects during infection.
AB - C/D box snoRNAs (SNORDs)are a highly expressed class of non-coding RNAs. Besides their well-established role in rRNA modification, C/D box snoRNAs form protein complexes devoid of fibrillarin and regulate pre-mRNA splicing and polyadenylation of numerous genes. There is an emerging body of evidence for functional interactions between RNA viruses and C/D box snoRNAs. The infectivity of some RNA viruses depends on enzymatically active fibrillarin, and many RNA viral proteins associate with nucleolin or nucleophosmin, suggesting that viruses benefit from their cytosolic accumulation. These interactions are likely reflected by morphological changes in the nucleolus, often leading to relocalization of nucleolar proteins and ncRNAs to the cytosol that are a characteristic feature of viral infections. Knock-down studies have also shown that RNA viruses need specific C/D box snoRNAs for optimal replication, suggesting that RNA viruses benefit from gene expression programs regulated by SNORDs, or that viruses have evolved “new” uses for these humble ncRNAs to advance their prospects during infection.
UR - http://www.scopus.com/inward/record.url?scp=85062272623&partnerID=8YFLogxK
U2 - 10.1016/j.ncrna.2019.02.001
DO - 10.1016/j.ncrna.2019.02.001
M3 - Review article
AN - SCOPUS:85062272623
SN - 2468-0540
VL - 4
SP - 46
EP - 53
JO - Non-coding RNA Research
JF - Non-coding RNA Research
IS - 2
ER -