Characterization of RVFV Nucleocapsid Protein Binding Sites on RNA by iCLIP-seq

Miyuki Hayashi, J. Stephen Lodmell

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The nucleocapsid protein (N) in Rift Valley fever virus is an RNA-binding protein that functions in viral transcription, replication, and packaging. In this chapter, the method for studying protein-RNA interactions in context of viral infection using individual nucleotide resolution, cross-linking, immunoprecipitation, and sequencing (iCLIP-seq) is explained. The method is useful for identifying the interactions between both host and viral RNAs with N and can identify RNA motifs that interact with the protein of interest.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages319-334
Number of pages16
DOIs
StatePublished - 2024

Publication series

NameMethods in Molecular Biology
Volume2824
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • iCLIP
  • Nucleocapsid protein
  • Rift Valley fever virus
  • RNA

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