Consumption of blueberry polyphenols reduces exercise-induced oxidative stress compared to vitamin C

Steven R. McAnulty, Lisa S. McAnulty, David C. Nieman, Charles L. Dumke, Jason D. Morrow, Alan C. Utter, Dru A. Henson, William R. Proulx, Gretchen L. George

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


This study examined whether blueberries or vitamin C consumed for 7 days in a randomized, double-blind, crossover design would attenuate oxidative stress and cytokine changes versus placebo. Nine subjects ran at 70% VO 2max in a hyperthermic environment (35°C, 70% relative humidity [RH]) until a core temperature of 39.5°C was reached, and for an equivalent time and intensity in the two remaining treatments. Blood samples were drawn before exercise and immediately, 15 minutes, and 30 minutes after exercise. Plasma samples were analyzed for F2-isoprostanes, lipid hydroperoxides, vitamin C, ferric reducing antioxidant potential, urate, interleukin-1ra, interleukin-6, interleukin-8, and interleukin-10. The pattern of change between treatments was significant for lipid hydroperoxides but not for any other marker. Significant correlations were found between F 2-isoprostanes, lipid hydroperoxides, ferric reducing antioxidant potential, and urate. This study indicates that blueberry supplementation may be beneficial for athletes exercising in hot environments.

Original languageEnglish
Pages (from-to)209-221
Number of pages13
JournalNutrition Research
Issue number3
StatePublished - Mar 2004


  • Antioxidants
  • Hyperthermia
  • Immune function
  • Polyphenols
  • Radicals


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