@article{27e08d0b85be4c17b533b7341d835b63,
title = "Consumption of blueberry polyphenols reduces exercise-induced oxidative stress compared to vitamin C",
abstract = "This study examined whether blueberries or vitamin C consumed for 7 days in a randomized, double-blind, crossover design would attenuate oxidative stress and cytokine changes versus placebo. Nine subjects ran at 70% VO 2max in a hyperthermic environment (35°C, 70% relative humidity [RH]) until a core temperature of 39.5°C was reached, and for an equivalent time and intensity in the two remaining treatments. Blood samples were drawn before exercise and immediately, 15 minutes, and 30 minutes after exercise. Plasma samples were analyzed for F2-isoprostanes, lipid hydroperoxides, vitamin C, ferric reducing antioxidant potential, urate, interleukin-1ra, interleukin-6, interleukin-8, and interleukin-10. The pattern of change between treatments was significant for lipid hydroperoxides but not for any other marker. Significant correlations were found between F 2-isoprostanes, lipid hydroperoxides, ferric reducing antioxidant potential, and urate. This study indicates that blueberry supplementation may be beneficial for athletes exercising in hot environments.",
keywords = "Antioxidants, Hyperthermia, Immune function, Polyphenols, Radicals",
author = "McAnulty, {Steven R.} and McAnulty, {Lisa S.} and Nieman, {David C.} and Dumke, {Charles L.} and Morrow, {Jason D.} and Utter, {Alan C.} and Henson, {Dru A.} and Proulx, {William R.} and George, {Gretchen L.}",
note = "Funding Information: This work was funded by the North American Blueberry Council and National Institutes of Health Grants (to J.D. Morrow) DK-48831, GM-15431, CA-77839, and DK-26657. J.D. Morrow is the recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research. Fischer/Nycom Laboratory. All authors contributed substantially to the completion of this project. Steven R. McAnulty and Lisa McAnulty were the primary project investigators and actively participated in data collection as phlebotomists, in laboratory and statistical analysis of data, and in preparation of the manuscript. David C. Nieman was the project cytokine specialist, primary statistician, and contributed to the writing and editing of the manuscript. Charles L. Dumke was active in data collection and editing of the manuscript. Alan C. Utter contributed to data collection, statistical analysis, and editing of the manuscript. Jason D. Morrow provided GC-MS analysis of the samples for F2-isoprostanes and contributed substantially to the manuscript discussion. Dru A. Henson was responsible for the determination of sample cytokine concentrations. Gretchen George supervised the subject cross-over schedules and was solely responsible for daily administration of all appropriate supplements. William Proulx was responsible for the initial grant contact and actively participated in the project design and data collection. ",
year = "2004",
month = mar,
doi = "10.1016/j.nutres.2003.10.003",
language = "English",
volume = "24",
pages = "209--221",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "3",
}
