Controlled release of interleukin-2 from biodegradable microspheres

Maninder Singh Hora, Rajsharan K. Rana, Jack H. Nunberg, Thomas R. Tice, Richard M. Gilley, Michael E. Hudson

Research output: Contribution to journalArticlepeer-review

Abstract

We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of inter-leukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioac-tive form continuously over a 20- to 30-day period.

Original languageEnglish
Pages (from-to)755-758
Number of pages4
JournalBio/Technology
Volume8
Issue number8
DOIs
StatePublished - Aug 1990

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