Controlled release of interleukin-2 from biodegradable microspheres

Maninder Singh Hora; Rajsharan K. Rana; Jack H. Nunberg; Thomas R. Tice; Richard M. Gilley; Michael E. Hudson

doi:10.1038/nbt0890-755

Controlled release of interleukin-2 from biodegradable microspheres

Maninder Singh Hora, Rajsharan K. Rana, Jack H. Nunberg, Thomas R. Tice, Richard M. Gilley, Michael E. Hudson

Montana Biotechnology Center

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of inter-leukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioac-tive form continuously over a 20- to 30-day period.

Original language	English
Pages (from-to)	755-758
Number of pages	4
Journal	Bio/Technology
Volume	8
Issue number	8
DOIs	https://doi.org/10.1038/nbt0890-755
State	Published - Aug 1990

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title = "Controlled release of interleukin-2 from biodegradable microspheres",

abstract = "We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of inter-leukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioac-tive form continuously over a 20- to 30-day period.",

author = "Hora, {Maninder Singh} and Rana, {Rajsharan K.} and Nunberg, {Jack H.} and Tice, {Thomas R.} and Gilley, {Richard M.} and Hudson, {Michael E.}",

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AU - Hora, Maninder Singh

AU - Rana, Rajsharan K.

AU - Nunberg, Jack H.

AU - Tice, Thomas R.

AU - Gilley, Richard M.

AU - Hudson, Michael E.

PY - 1990/8

Y1 - 1990/8

N2 - We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of inter-leukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioac-tive form continuously over a 20- to 30-day period.

AB - We have evaluated the use of biodegradable poly(DL-lactide-co-glycolide) microspheres for the controlled release of inter-leukin-2 (IL-2) and its modified forms: succinyl IL-2 (SIL-2) and polyethylene glycol-modified IL-2 (PEG IL-2). We show that a microsphere formulation can be prepared from PEG IL-2 using HSA as an excipient which, after an initial burst, releases 2-3% PEG IL-2 per day in a bioac-tive form continuously over a 20- to 30-day period.

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IS - 8

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Controlled release of interleukin-2 from biodegradable microspheres

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