Controlling self-assembly of a peptide-based material via metal-ion induced registry shift

Paolo Anzini; Chunfu Xu; Spencer Hughes; Elizabeth Magnotti; Tao Jiang; Lars Hemmingsen; Borries Demeler; Vincent P. Conticello

doi:10.1021/ja404677c

Controlling self-assembly of a peptide-based material via metal-ion induced registry shift

Paolo Anzini, Chunfu Xu, Spencer Hughes, Elizabeth Magnotti, Tao Jiang, Lars Hemmingsen, Borries Demeler, Vincent P. Conticello

Chemistry

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Peptide TZ1C2 can populate two distinct orientations: a staggered (out-of-register) fibril and an aligned (in-register) coiled-coil trimer. The coordination of two cadmium ions induces a registry shift that results in a reversible transition between these structural forms. This process recapitulates the self-assembly mechanism of native protein fibrils in which a ligand binding event gates a reversible conformational transition between alternate forms of a folded peptide structure.

Original language	English
Pages (from-to)	10278-10281
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	28
DOIs	https://doi.org/10.1021/ja404677c
State	Published - Jul 17 2013

Access to Document

10.1021/ja404677c

Cite this

@article{eea06963cd0d4bda8a2f698490e6081a,

title = "Controlling self-assembly of a peptide-based material via metal-ion induced registry shift",

abstract = "Peptide TZ1C2 can populate two distinct orientations: a staggered (out-of-register) fibril and an aligned (in-register) coiled-coil trimer. The coordination of two cadmium ions induces a registry shift that results in a reversible transition between these structural forms. This process recapitulates the self-assembly mechanism of native protein fibrils in which a ligand binding event gates a reversible conformational transition between alternate forms of a folded peptide structure.",

author = "Paolo Anzini and Chunfu Xu and Spencer Hughes and Elizabeth Magnotti and Tao Jiang and Lars Hemmingsen and Borries Demeler and Conticello, {Vincent P.}",

year = "2013",

month = jul,

day = "17",

doi = "10.1021/ja404677c",

language = "English",

volume = "135",

pages = "10278--10281",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "28",

}

TY - JOUR

T1 - Controlling self-assembly of a peptide-based material via metal-ion induced registry shift

AU - Anzini, Paolo

AU - Xu, Chunfu

AU - Hughes, Spencer

AU - Magnotti, Elizabeth

AU - Jiang, Tao

AU - Hemmingsen, Lars

AU - Demeler, Borries

AU - Conticello, Vincent P.

PY - 2013/7/17

Y1 - 2013/7/17

N2 - Peptide TZ1C2 can populate two distinct orientations: a staggered (out-of-register) fibril and an aligned (in-register) coiled-coil trimer. The coordination of two cadmium ions induces a registry shift that results in a reversible transition between these structural forms. This process recapitulates the self-assembly mechanism of native protein fibrils in which a ligand binding event gates a reversible conformational transition between alternate forms of a folded peptide structure.

AB - Peptide TZ1C2 can populate two distinct orientations: a staggered (out-of-register) fibril and an aligned (in-register) coiled-coil trimer. The coordination of two cadmium ions induces a registry shift that results in a reversible transition between these structural forms. This process recapitulates the self-assembly mechanism of native protein fibrils in which a ligand binding event gates a reversible conformational transition between alternate forms of a folded peptide structure.

UR - http://www.scopus.com/inward/record.url?scp=84880374874&partnerID=8YFLogxK

U2 - 10.1021/ja404677c

DO - 10.1021/ja404677c

M3 - Article

C2 - 23815081

AN - SCOPUS:84880374874

SN - 0002-7863

VL - 135

SP - 10278

EP - 10281

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 28

ER -

Controlling self-assembly of a peptide-based material via metal-ion induced registry shift

Abstract

Access to Document

Other files and links

Fingerprint

Cite this