TY - JOUR
T1 - Crystal structure of ethyl 4-[4-(dimethylamino)phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
AU - Steiger, Scott A.
AU - Li, Chun
AU - Natale, Nicholas R.
N1 - Publisher Copyright:
© © Steiger et al. 2018.
PY - 2018
Y1 - 2018
N2 - In the title racemic compound, ethyl 4-(4-dimethylaminophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, the common structural features in this type of compound, such as the flat-boat conformation of the 1,4-dihydropyridine (1,4-DHP) ring, the envelope conformation of the fused cyclohexanone, and the substituted phenyl ring at the pseudo-axial position and orthogonal to the 1,4-DHP ring, are present. In the crystal, molecules are linked via N - H⋯O and C - H⋯O hydrogen bonds, forming layers parallel to the (10) plane.
AB - In the title racemic compound, ethyl 4-(4-dimethylaminophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, the common structural features in this type of compound, such as the flat-boat conformation of the 1,4-dihydropyridine (1,4-DHP) ring, the envelope conformation of the fused cyclohexanone, and the substituted phenyl ring at the pseudo-axial position and orthogonal to the 1,4-DHP ring, are present. In the crystal, molecules are linked via N - H⋯O and C - H⋯O hydrogen bonds, forming layers parallel to the (10) plane.
KW - 1,4-dihydropyridine rings
KW - 4-aryl-hexahydroquinolines
KW - calcium-channel antagonists
KW - crystal structure
KW - hydrogen bonding
KW - structure-activity relationships
UR - http://www.scopus.com/inward/record.url?scp=85054572138&partnerID=8YFLogxK
U2 - 10.1107/S2056989018011982
DO - 10.1107/S2056989018011982
M3 - Article
AN - SCOPUS:85054572138
SN - 2056-9890
VL - 74
SP - 1417
EP - 1420
JO - Acta Crystallographica Section E: Crystallographic Communications
JF - Acta Crystallographica Section E: Crystallographic Communications
ER -