Crystal structure of ethyl 4-[4-(dimethylamino)phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Scott A. Steiger, Chun Li, Nicholas R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

In the title racemic compound, ethyl 4-(4-dimethylaminophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, the common structural features in this type of compound, such as the flat-boat conformation of the 1,4-dihydropyridine (1,4-DHP) ring, the envelope conformation of the fused cyclohexanone, and the substituted phenyl ring at the pseudo-axial position and orthogonal to the 1,4-DHP ring, are present. In the crystal, molecules are linked via N - H⋯O and C - H⋯O hydrogen bonds, forming layers parallel to the (10) plane.

Original languageEnglish
Pages (from-to)1417-1420
Number of pages4
JournalActa Crystallographica Section E: Crystallographic Communications
Volume74
DOIs
StatePublished - 2018

Keywords

  • 1,4-dihydropyridine rings
  • 4-aryl-hexahydroquinolines
  • calcium-channel antagonists
  • crystal structure
  • hydrogen bonding
  • structure-activity relationships

Fingerprint

Dive into the research topics of 'Crystal structure of ethyl 4-[4-(dimethylamino)phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate'. Together they form a unique fingerprint.

Cite this