Cu(I) luminescence from the tetranuclear Cu4S4 cofactor of a synthetic 4-helix bundle

Olesya A. Kharenko; David C. Kennedy; Borries Demeler; Michael J. Maroney; Michael Y. Ogawa

doi:10.1021/ja042757m

Cu(I) luminescence from the tetranuclear Cu₄S₄ cofactor of a synthetic 4-helix bundle

Olesya A. Kharenko, David C. Kennedy, Borries Demeler, Michael J. Maroney, Michael Y. Ogawa

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The addition of Cu(I) to the random-coil peptide, C16C19-GGY, produces a self-organized, metal-bridged 4-helix bundle which displays an intense room-temperature luminescence at 600 nm. Emission, UV, and CD titrations along with X-ray absorption studies indicate that the luminescent cofactor is likely a Cu₄S₄ cluster in which each Cu atom is bridged by the side chains of two cysteine residues and has terminal N/O ligation.

Original language	English
Pages (from-to)	7678-7679
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	21
DOIs	https://doi.org/10.1021/ja042757m
State	Published - Jun 1 2005

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title = "Cu(I) luminescence from the tetranuclear Cu4S4 cofactor of a synthetic 4-helix bundle",

abstract = "The addition of Cu(I) to the random-coil peptide, C16C19-GGY, produces a self-organized, metal-bridged 4-helix bundle which displays an intense room-temperature luminescence at 600 nm. Emission, UV, and CD titrations along with X-ray absorption studies indicate that the luminescent cofactor is likely a Cu4S4 cluster in which each Cu atom is bridged by the side chains of two cysteine residues and has terminal N/O ligation.",

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T1 - Cu(I) luminescence from the tetranuclear Cu4S4 cofactor of a synthetic 4-helix bundle

AU - Kharenko, Olesya A.

AU - Kennedy, David C.

AU - Demeler, Borries

AU - Maroney, Michael J.

AU - Ogawa, Michael Y.

PY - 2005/6/1

Y1 - 2005/6/1

N2 - The addition of Cu(I) to the random-coil peptide, C16C19-GGY, produces a self-organized, metal-bridged 4-helix bundle which displays an intense room-temperature luminescence at 600 nm. Emission, UV, and CD titrations along with X-ray absorption studies indicate that the luminescent cofactor is likely a Cu4S4 cluster in which each Cu atom is bridged by the side chains of two cysteine residues and has terminal N/O ligation.

AB - The addition of Cu(I) to the random-coil peptide, C16C19-GGY, produces a self-organized, metal-bridged 4-helix bundle which displays an intense room-temperature luminescence at 600 nm. Emission, UV, and CD titrations along with X-ray absorption studies indicate that the luminescent cofactor is likely a Cu4S4 cluster in which each Cu atom is bridged by the side chains of two cysteine residues and has terminal N/O ligation.

UR - https://www.scopus.com/pages/publications/19744379906

U2 - 10.1021/ja042757m

DO - 10.1021/ja042757m

M3 - Article

C2 - 15913348

AN - SCOPUS:19744379906

SN - 0002-7863

VL - 127

SP - 7678

EP - 7679

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 21

ER -

Cu(I) luminescence from the tetranuclear Cu₄S₄ cofactor of a synthetic 4-helix bundle

Abstract

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