Cutting edge: Class I presentation of host peptides following HIV infection

Heather D. Hickman, Angela D. Luis, Wilfried Bardet, Rico Buchli, Casey L. Battson, Michael H. Shearer, Kenneth W. Jackson, Ronald C. Kennedy, William H. Hildebrand

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Class I MHC molecules bind intracellular peptides for presentation to cytotoxic T lymphocytes. Identification of peptides presented by class I molecules during infection is therefore a priority for detecting and targeting intracellular pathogens. To understand which host-encoded peptides distinguish HIV-infected cells, we have developed a mass spectrometric approach to characterize HLA-B*0702 peptides unique to or up-regulated on infected T cells. In this study, we identify 15 host proteins that are differentially presented on infected human T cells. Pep-tides with increased expression on HIV-infected cells were derived from multiple categories of cellular proteins including RNA binding proteins and cell cycle regulatory proteins. Therefore, comprehensive analysis of the B*0702 peptide repertoire demonstrates that marked differences in host protein presentation occur after HIV infection.

    Original languageEnglish
    Pages (from-to)22-26
    Number of pages5
    JournalJournal of Immunology
    Volume171
    Issue number1
    DOIs
    StatePublished - Jul 1 2003

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