Cytokine structural taxonomy and mechanisms of receptor engagement. Current opinion in structural biology 1993, 3:815-827

Stephen R. Sprang, J. Fernando Bazan

Research output: Contribution to journalArticlepeer-review

Abstract

Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.

Original languageEnglish
Pages (from-to)815-827
Number of pages13
JournalCurrent Opinion in Structural Biology
Volume3
Issue number6
DOIs
StatePublished - 1993

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