Cytokine structural taxonomy and mechanisms of receptor engagement. Current opinion in structural biology 1993, 3:815-827

Stephen R. Sprang; J. Fernando Bazan

doi:10.1016/0959-440X(93)90144-A

Cytokine structural taxonomy and mechanisms of receptor engagement. Current opinion in structural biology 1993, 3:815-827

Stephen R. Sprang
, J. Fernando Bazan

Division of Biological and Biomedical Sciences

University of Texas Southwestern Medical Center

Research output: Contribution to journal › Article › peer-review

251 Scopus citations

Abstract

Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.

Original language	English
Pages (from-to)	815-827
Number of pages	13
Journal	Current Opinion in Structural Biology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/0959-440X(93)90144-A
State	Published - 1993

Funding

Work at the DNAX Research Institute is supported by Schering Plough. We are grateful to our colleagues who gave us access to their atomic coordinates before public release.

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10.1016/0959-440X(93)90144-A

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title = "Cytokine structural taxonomy and mechanisms of receptor engagement. Current opinion in structural biology 1993, 3:815-827",

abstract = "Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.",

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AB - Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.

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Cytokine structural taxonomy and mechanisms of receptor engagement. Current opinion in structural biology 1993, 3:815-827

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