Abstract
Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.
| Original language | English |
|---|---|
| Pages (from-to) | 815-827 |
| Number of pages | 13 |
| Journal | Current Opinion in Structural Biology |
| Volume | 3 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1993 |
Funding
Work at the DNAX Research Institute is supported by Schering Plough. We are grateful to our colleagues who gave us access to their atomic coordinates before public release.