Design and synthesis of a novel intercalating isoxazolyl bis-lexitropsin conjugate

9-Anthracene nitrile oxide directly generated from 9-anthracenealdoxime and N-chlorosuccinamide (NCS), reacts with dimethyl acetylenedicarboxylate (DMAD) and affords the corresponding 3-(9′-anthracenyl)-isoxazole-4,5-dicarboxylic acid ester (3) with good yield in a very short period. Double activation reaction between (3) and hydrogenated lexitropsin (5) in a 1:2 molar ratio, produced a bis-lexitropsin product (6) (major product) and mono-lexitropsin product (7).