Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve

Jeff S. Piotrowski; Saisubramanian Nagarajan; Eugene Kroll; Alison Stanbery; Kami E. Chiotti; Arthur L. Kruckeberg; Barbara Dunn; Gavin Sherlock; Frank Rosenzweig

doi:10.1186/1471-2148-12-46

Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve

Jeff S. Piotrowski
, Saisubramanian Nagarajan
, Eugene Kroll
, Alison Stanbery
, Kami E. Chiotti
, Arthur L. Kruckeberg
, Barbara Dunn
, Gavin Sherlock
, Frank Rosenzweig

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Interspecific hybridization occurs in every eukaryotic kingdom. While hybrid progeny are frequently at a selective disadvantage, in some instances their increased genome size and complexity may result in greater stress resistance than their ancestors, which can be adaptively advantageous at the edges of their ancestors' ranges. While this phenomenon has been repeatedly documented in the field, the response of hybrid populations to long-term selection has not often been explored in the lab. To fill this knowledge gap we crossed the two most distantly related members of the Saccharomyces sensu stricto group, S. cerevisiae and S. uvarum, and established a mixed population of homoploid and aneuploid hybrids to study how different types of selection impact hybrid genome structure.

Original language	English
Article number	46
Journal	BMC Evolutionary Biology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1471-2148-12-46
State	Published - 2012

Funding

The authors wish to thank Carla Boulianne-Larsen and Jeff Good for critically reading the manuscript. Gregory Koniges performed heat shock experiments to distinguish between induced and inherent thermal resistance. Flow cytometry was performed with the assistance of Pamela Shaw. We thank Minoru Yoshida and Astellas Pharma for the use of Micafungin. This work was supported by grants to GS from Global Climate and Energy Project (Grant #33450) and to FR from NASA NNX07AJ28G, as well as by NIH grant P20RR017670 to the University of Montana Fluorescence Cytometry Core Facility.

Funders	Funder number
P20RR017670
National Aeronautics and Space Administration	NNX07AJ28G

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title = "Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve",

abstract = "Interspecific hybridization occurs in every eukaryotic kingdom. While hybrid progeny are frequently at a selective disadvantage, in some instances their increased genome size and complexity may result in greater stress resistance than their ancestors, which can be adaptively advantageous at the edges of their ancestors' ranges. While this phenomenon has been repeatedly documented in the field, the response of hybrid populations to long-term selection has not often been explored in the lab. To fill this knowledge gap we crossed the two most distantly related members of the Saccharomyces sensu stricto group, S. cerevisiae and S. uvarum, and established a mixed population of homoploid and aneuploid hybrids to study how different types of selection impact hybrid genome structure.",

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note = "Funding Information: The authors wish to thank Carla Boulianne-Larsen and Jeff Good for critically reading the manuscript. Gregory Koniges performed heat shock experiments to distinguish between induced and inherent thermal resistance. Flow cytometry was performed with the assistance of Pamela Shaw. We thank Minoru Yoshida and Astellas Pharma for the use of Micafungin. This work was supported by grants to GS from Global Climate and Energy Project (Grant \#33450) and to FR from NASA NNX07AJ28G, as well as by NIH grant P20RR017670 to the University of Montana Fluorescence Cytometry Core Facility.",

year = "2012",

doi = "10.1186/1471-2148-12-46",

language = "English",

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journal = "BMC Evolutionary Biology",

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AU - Piotrowski, Jeff S.

AU - Nagarajan, Saisubramanian

AU - Kroll, Eugene

AU - Stanbery, Alison

AU - Chiotti, Kami E.

AU - Kruckeberg, Arthur L.

AU - Dunn, Barbara

AU - Sherlock, Gavin

AU - Rosenzweig, Frank

N1 - Funding Information: The authors wish to thank Carla Boulianne-Larsen and Jeff Good for critically reading the manuscript. Gregory Koniges performed heat shock experiments to distinguish between induced and inherent thermal resistance. Flow cytometry was performed with the assistance of Pamela Shaw. We thank Minoru Yoshida and Astellas Pharma for the use of Micafungin. This work was supported by grants to GS from Global Climate and Energy Project (Grant #33450) and to FR from NASA NNX07AJ28G, as well as by NIH grant P20RR017670 to the University of Montana Fluorescence Cytometry Core Facility.

PY - 2012

Y1 - 2012

N2 - Interspecific hybridization occurs in every eukaryotic kingdom. While hybrid progeny are frequently at a selective disadvantage, in some instances their increased genome size and complexity may result in greater stress resistance than their ancestors, which can be adaptively advantageous at the edges of their ancestors' ranges. While this phenomenon has been repeatedly documented in the field, the response of hybrid populations to long-term selection has not often been explored in the lab. To fill this knowledge gap we crossed the two most distantly related members of the Saccharomyces sensu stricto group, S. cerevisiae and S. uvarum, and established a mixed population of homoploid and aneuploid hybrids to study how different types of selection impact hybrid genome structure.

AB - Interspecific hybridization occurs in every eukaryotic kingdom. While hybrid progeny are frequently at a selective disadvantage, in some instances their increased genome size and complexity may result in greater stress resistance than their ancestors, which can be adaptively advantageous at the edges of their ancestors' ranges. While this phenomenon has been repeatedly documented in the field, the response of hybrid populations to long-term selection has not often been explored in the lab. To fill this knowledge gap we crossed the two most distantly related members of the Saccharomyces sensu stricto group, S. cerevisiae and S. uvarum, and established a mixed population of homoploid and aneuploid hybrids to study how different types of selection impact hybrid genome structure.

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VL - 12

JO - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

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ER -

Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve

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