Double activation preparation of an acridinyl-isoxazolyl-lexitropsin

Peiwen Zhou; Michael D. Mosher; Wendy D. Taylor; Gregory A. Crawford; N. R. Natale

doi:10.1016/S0960-894X(97)10011-7

Double activation preparation of an acridinyl-isoxazolyl-lexitropsin

Peiwen Zhou, Michael D. Mosher, Wendy D. Taylor, Gregory A. Crawford, N. R. Natale

University of Idaho

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The coupling of a sterically hindered acridinyl isoxazole ester directly to the amine group of a lexitropsin is significantly improved by double activation, using trimethylaluminum to activate the amine portion and samarium (III) chloride to enhance the carboxylate reactivity.

Original language	English
Pages (from-to)	2455-2456
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(97)10011-7
State	Published - Oct 7 1997

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title = "Double activation preparation of an acridinyl-isoxazolyl-lexitropsin",

abstract = "The coupling of a sterically hindered acridinyl isoxazole ester directly to the amine group of a lexitropsin is significantly improved by double activation, using trimethylaluminum to activate the amine portion and samarium (III) chloride to enhance the carboxylate reactivity.",

author = "Peiwen Zhou and Mosher, {Michael D.} and Taylor, {Wendy D.} and Crawford, {Gregory A.} and Natale, {N. R.}",

year = "1997",

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T1 - Double activation preparation of an acridinyl-isoxazolyl-lexitropsin

AU - Zhou, Peiwen

AU - Mosher, Michael D.

AU - Taylor, Wendy D.

AU - Crawford, Gregory A.

AU - Natale, N. R.

PY - 1997/10/7

Y1 - 1997/10/7

N2 - The coupling of a sterically hindered acridinyl isoxazole ester directly to the amine group of a lexitropsin is significantly improved by double activation, using trimethylaluminum to activate the amine portion and samarium (III) chloride to enhance the carboxylate reactivity.

AB - The coupling of a sterically hindered acridinyl isoxazole ester directly to the amine group of a lexitropsin is significantly improved by double activation, using trimethylaluminum to activate the amine portion and samarium (III) chloride to enhance the carboxylate reactivity.

UR - http://www.scopus.com/inward/record.url?scp=0030754734&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(97)10011-7

DO - 10.1016/S0960-894X(97)10011-7

M3 - Article

AN - SCOPUS:0030754734

SN - 0960-894X

VL - 7

SP - 2455

EP - 2456

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Double activation preparation of an acridinyl-isoxazolyl-lexitropsin

Abstract

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