Double activation preparation of an acridinyl-isoxazolyl-lexitropsin

Peiwen Zhou, Michael D. Mosher, Wendy D. Taylor, Gregory A. Crawford, N. R. Natale

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The coupling of a sterically hindered acridinyl isoxazole ester directly to the amine group of a lexitropsin is significantly improved by double activation, using trimethylaluminum to activate the amine portion and samarium (III) chloride to enhance the carboxylate reactivity.

Original languageEnglish
Pages (from-to)2455-2456
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
StatePublished - Oct 7 1997


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