Effect of NSAID on muscle injury and oxidative stress

Steven McAnulty, L. McAnulty, D. Nieman, J. Morrow, C. Dumke, D. Henson

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Indirect markers of muscle damage and delayed onset muscle soreness were examined and correlated to changes in oxidative stress, plasma antioxidant potential, and use or nonuse of non-steroidal anti-inflammatory drugs in 60 ultra-marathoners following the Western States Endurance Run. Blood was collected prior to and immediately following the race and analyzed for muscle damage by creatine phosphokinase and oxidative stress by F2- isoprostanes, protein carbonyls, and lipid hydroperoxides and antioxidant potential by the ferric reducing ability of plasma. Subjects recorded delayed onset muscle soreness during the week following the race. Lipid hydroperoxide concentrations were unchanged, but F2-isoprostanes, protein carbonyls, ferric reducing ability of plasma, creatine phosphokinase, and delayed onset muscle soreness increased significantly postrace. Protein carbonyls were significantly higher postrace in nonsteroidal anti-inflammatory drug users versus nonusers (p < 0.05). However, there was no difference between users and non-users for all other markers. Postrace creatine Phosphokinase concentrations were not correlated with oxidative stress markers but were correlated with changes in delayed onset muscle soreness. Based upon these findings, caution should be used when consuming nonsteroidal anti-inflammatory drugs during ultra distance events.

Original languageEnglish
Pages (from-to)909-915
Number of pages7
JournalInternational Journal of Sports Medicine
Issue number11
StatePublished - Nov 2007


  • Antioxidant potential
  • Drugs
  • Exercise
  • Lipid oxidation
  • Protein oxidation


Dive into the research topics of 'Effect of NSAID on muscle injury and oxidative stress'. Together they form a unique fingerprint.

Cite this