TY - JOUR
T1 - Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography
AU - Shi, Wei
AU - Peterson, Dominic S.
AU - Palmer, Christopher P.
N1 - Funding Information:
The authors would like to acknowledge major funding for this work provided by the Department of Energy (Sandia National Laboratories) through a Presidential Early Career Award. Thanks also go to Professor Fuierer and Lee Benysek of the Department of Material Sciences for assistance with light scattering experiments.
PY - 2001/7/27
Y1 - 2001/7/27
N2 - Amphiphilic copolymers of AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and hydrophobic monomers with various chemical structures were synthesized, characterized and used as novel electrokinetic chromatography polymeric pseudo-stationary phases, showing significant chemical selectivity differences from that of the conventional monomeric pseudo-stationary phase, sodium lauryl sulphate. Copolymers of AMPS and methacrylates with different pendant chain lengths (C8, C12 and C18) were investigated and no significant difference in chemical selectivity was observed among them. However, the spacer bonding chemistry was shown to contribute to significant chemical selectivity difference, e.g. poly(AMPS-lauryl methacrylate) showed different chemical selectivity from poly(AMPS-lauryl methacrylamide). Linear solvation energy relationship analysis of 20 solutes by eight different polymeric pseudo-stationary phases was employed to investigate the solute molecule structural contributions to the retention. Hydrogen-bonding properties (described by system constants b and a) of poly(AMPS-alkyl methacrylamide) were found stronger than those of poly(AMPS-alkyl methacrylate).
AB - Amphiphilic copolymers of AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and hydrophobic monomers with various chemical structures were synthesized, characterized and used as novel electrokinetic chromatography polymeric pseudo-stationary phases, showing significant chemical selectivity differences from that of the conventional monomeric pseudo-stationary phase, sodium lauryl sulphate. Copolymers of AMPS and methacrylates with different pendant chain lengths (C8, C12 and C18) were investigated and no significant difference in chemical selectivity was observed among them. However, the spacer bonding chemistry was shown to contribute to significant chemical selectivity difference, e.g. poly(AMPS-lauryl methacrylate) showed different chemical selectivity from poly(AMPS-lauryl methacrylamide). Linear solvation energy relationship analysis of 20 solutes by eight different polymeric pseudo-stationary phases was employed to investigate the solute molecule structural contributions to the retention. Hydrogen-bonding properties (described by system constants b and a) of poly(AMPS-alkyl methacrylamide) were found stronger than those of poly(AMPS-alkyl methacrylate).
KW - Electrokinetic chromatography
KW - Linear solvation energy relationships
KW - Methacrylamide
KW - Methacrylate
KW - Pseudo-stationary phases
UR - http://www.scopus.com/inward/record.url?scp=0035958575&partnerID=8YFLogxK
U2 - 10.1016/S0021-9673(01)00760-9
DO - 10.1016/S0021-9673(01)00760-9
M3 - Article
C2 - 11521859
AN - SCOPUS:0035958575
SN - 0021-9673
VL - 924
SP - 123
EP - 135
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1-2
ER -