Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography

Wei Shi; Dominic S. Peterson; Christopher P. Palmer

doi:10.1016/S0021-9673(01)00760-9

Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography

Wei Shi
, Dominic S. Peterson
, Christopher P. Palmer

Chemistry and Biochemistry

New Mexico Institute of Mining and Technology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Amphiphilic copolymers of AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and hydrophobic monomers with various chemical structures were synthesized, characterized and used as novel electrokinetic chromatography polymeric pseudo-stationary phases, showing significant chemical selectivity differences from that of the conventional monomeric pseudo-stationary phase, sodium lauryl sulphate. Copolymers of AMPS and methacrylates with different pendant chain lengths (C₈, C₁₂ and C₁₈) were investigated and no significant difference in chemical selectivity was observed among them. However, the spacer bonding chemistry was shown to contribute to significant chemical selectivity difference, e.g. poly(AMPS-lauryl methacrylate) showed different chemical selectivity from poly(AMPS-lauryl methacrylamide). Linear solvation energy relationship analysis of 20 solutes by eight different polymeric pseudo-stationary phases was employed to investigate the solute molecule structural contributions to the retention. Hydrogen-bonding properties (described by system constants b and a) of poly(AMPS-alkyl methacrylamide) were found stronger than those of poly(AMPS-alkyl methacrylate).

Original language	English
Pages (from-to)	123-135
Number of pages	13
Journal	Journal of Chromatography A
Volume	924
Issue number	1-2
DOIs	https://doi.org/10.1016/S0021-9673(01)00760-9
State	Published - Jul 27 2001

Funding

The authors would like to acknowledge major funding for this work provided by the Department of Energy (Sandia National Laboratories) through a Presidential Early Career Award. Thanks also go to Professor Fuierer and Lee Benysek of the Department of Material Sciences for assistance with light scattering experiments.

Funders
Sandia National Laboratories

Keywords

Electrokinetic chromatography
Linear solvation energy relationships
Methacrylamide
Methacrylate
Pseudo-stationary phases

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10.1016/S0021-9673(01)00760-9

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@article{322f3560416644e18782312c6e84ae5e,

title = "Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography",

abstract = "Amphiphilic copolymers of AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and hydrophobic monomers with various chemical structures were synthesized, characterized and used as novel electrokinetic chromatography polymeric pseudo-stationary phases, showing significant chemical selectivity differences from that of the conventional monomeric pseudo-stationary phase, sodium lauryl sulphate. Copolymers of AMPS and methacrylates with different pendant chain lengths (C8, C12 and C18) were investigated and no significant difference in chemical selectivity was observed among them. However, the spacer bonding chemistry was shown to contribute to significant chemical selectivity difference, e.g. poly(AMPS-lauryl methacrylate) showed different chemical selectivity from poly(AMPS-lauryl methacrylamide). Linear solvation energy relationship analysis of 20 solutes by eight different polymeric pseudo-stationary phases was employed to investigate the solute molecule structural contributions to the retention. Hydrogen-bonding properties (described by system constants b and a) of poly(AMPS-alkyl methacrylamide) were found stronger than those of poly(AMPS-alkyl methacrylate).",

keywords = "Electrokinetic chromatography, Linear solvation energy relationships, Methacrylamide, Methacrylate, Pseudo-stationary phases",

author = "Wei Shi and Peterson, \{Dominic S.\} and Palmer, \{Christopher P.\}",

note = "Funding Information: The authors would like to acknowledge major funding for this work provided by the Department of Energy (Sandia National Laboratories) through a Presidential Early Career Award. Thanks also go to Professor Fuierer and Lee Benysek of the Department of Material Sciences for assistance with light scattering experiments.",

year = "2001",

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doi = "10.1016/S0021-9673(01)00760-9",

language = "English",

volume = "924",

pages = "123--135",

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Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography. / Shi, Wei; Peterson, Dominic S.; Palmer, Christopher P.
In: Journal of Chromatography A, Vol. 924, No. 1-2, 27.07.2001, p. 123-135.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography

AU - Shi, Wei

AU - Peterson, Dominic S.

AU - Palmer, Christopher P.

N1 - Funding Information: The authors would like to acknowledge major funding for this work provided by the Department of Energy (Sandia National Laboratories) through a Presidential Early Career Award. Thanks also go to Professor Fuierer and Lee Benysek of the Department of Material Sciences for assistance with light scattering experiments.

PY - 2001/7/27

Y1 - 2001/7/27

N2 - Amphiphilic copolymers of AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and hydrophobic monomers with various chemical structures were synthesized, characterized and used as novel electrokinetic chromatography polymeric pseudo-stationary phases, showing significant chemical selectivity differences from that of the conventional monomeric pseudo-stationary phase, sodium lauryl sulphate. Copolymers of AMPS and methacrylates with different pendant chain lengths (C8, C12 and C18) were investigated and no significant difference in chemical selectivity was observed among them. However, the spacer bonding chemistry was shown to contribute to significant chemical selectivity difference, e.g. poly(AMPS-lauryl methacrylate) showed different chemical selectivity from poly(AMPS-lauryl methacrylamide). Linear solvation energy relationship analysis of 20 solutes by eight different polymeric pseudo-stationary phases was employed to investigate the solute molecule structural contributions to the retention. Hydrogen-bonding properties (described by system constants b and a) of poly(AMPS-alkyl methacrylamide) were found stronger than those of poly(AMPS-alkyl methacrylate).

AB - Amphiphilic copolymers of AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid) and hydrophobic monomers with various chemical structures were synthesized, characterized and used as novel electrokinetic chromatography polymeric pseudo-stationary phases, showing significant chemical selectivity differences from that of the conventional monomeric pseudo-stationary phase, sodium lauryl sulphate. Copolymers of AMPS and methacrylates with different pendant chain lengths (C8, C12 and C18) were investigated and no significant difference in chemical selectivity was observed among them. However, the spacer bonding chemistry was shown to contribute to significant chemical selectivity difference, e.g. poly(AMPS-lauryl methacrylate) showed different chemical selectivity from poly(AMPS-lauryl methacrylamide). Linear solvation energy relationship analysis of 20 solutes by eight different polymeric pseudo-stationary phases was employed to investigate the solute molecule structural contributions to the retention. Hydrogen-bonding properties (described by system constants b and a) of poly(AMPS-alkyl methacrylamide) were found stronger than those of poly(AMPS-alkyl methacrylate).

KW - Electrokinetic chromatography

KW - Linear solvation energy relationships

KW - Methacrylamide

KW - Methacrylate

KW - Pseudo-stationary phases

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U2 - 10.1016/S0021-9673(01)00760-9

DO - 10.1016/S0021-9673(01)00760-9

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JO - Journal of Chromatography A

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IS - 1-2

ER -

Effect of pendant chain lengths and backbone functionalities on the chemical selectivity of sulfonated amphiphilic copolymers as pseudo-stationary phases in electrokinetic chromatography

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Keywords

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