Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer's and Parkinson's Diseases in Young Urbanites Exposed to Air Pollution

Lilian Calderon-Garciduenas, Ricardo Torres-Jardon, Maricela Franco-Lira, Randy Kulesza, Angelica Gonzalez-Maciel, Rafael Reynoso-Robles, Rafael Brito-Aguilar, Berenice Garcia-Arreola, Paula Revueltas-Ficachi, Juana Adriana Barrera-Velazquez, Griselda Garcia-Alonso, Edgar Garcia-Rojas, Partha S. Mukherjee, Ricardo Delgado-Chavez

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Alzheimer's and Parkinson's diseases (AD, PD) have a pediatric and young adult onset in Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering neurological complications and deep concern regarding acceleration of neuroinflammatory and neurodegenerative processes already in progress. This review, based on our MMC experience, will discuss two major issues: 1) why residents chronically exposed to air pollution are likely to be more susceptible to SARS-CoV-2 systemic and brain effects and 2) why young people with AD and PD already in progress will accelerate neurodegenerative processes. Secondary mental consequences of social distancing and isolation, fear, financial insecurity, violence, poor health support, and lack of understanding of the complex crisis are expected in MMC residents infected or free of SARS-CoV-2. MMC residents with pre-SARS-CoV-2 accumulation of misfolded proteins diagnostic of AD and PD and metal-rich, magnetic nanoparticles damaging key neural organelles are an ideal host for neurotropic SARS-CoV-2 RNA virus invading the body through the same portals damaged by nanoparticles: nasal olfactory epithelium, the gastrointestinal tract, and the alveolar-capillary portal. We urgently need MMC multicenter retrospective-prospective neurological and psychiatric population follow-up and intervention strategies in place in case of acceleration of neurodegenerative processes, increased risk of suicide, and mental disease worsening. Identification of vulnerable populations and continuous effort to lower air pollution ought to be critical steps.

Original languageEnglish
Pages (from-to)479-503
Number of pages25
JournalJournal of Alzheimer's Disease
Volume78
Issue number2
DOIs
StatePublished - 2020

Keywords

  • ACE2
  • Alzheimer's disease
  • COVID 19
  • Parkinson's disease
  • SARS-CoV-2
  • air pollution
  • depression
  • nanoparticles
  • neurotropism
  • suicide

Fingerprint

Dive into the research topics of 'Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer's and Parkinson's Diseases in Young Urbanites Exposed to Air Pollution'. Together they form a unique fingerprint.

Cite this