TY - JOUR
T1 - Ethyl 4-{1-[(2,4-dinitrophenyl)hydrazono]ethyl}-5-(2-naphthylmethoxy- methyl)isoxazole-3-carboxylate
AU - Natale, Nicholas R.
AU - Szabon-Watola, Monica I.
AU - Twamley, Brendan
AU - Bridges, Richard J.
AU - Patel, Sarjubhai
AU - Rajale, Trideep
PY - 2008
Y1 - 2008
N2 - The title compound, C26H23N5O8, was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004). Neuropharmacology, 46, 273-284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra-molecular N - H⋯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.
AB - The title compound, C26H23N5O8, was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004). Neuropharmacology, 46, 273-284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra-molecular N - H⋯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.
UR - http://www.scopus.com/inward/record.url?scp=58149467942&partnerID=8YFLogxK
U2 - 10.1107/S1600536808041901
DO - 10.1107/S1600536808041901
M3 - Article
AN - SCOPUS:58149467942
SN - 1600-5368
VL - 65
SP - o144-o145
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 1
ER -