Ethyl 4-{1-[(2,4-dinitrophenyl)hydrazono]ethyl}-5-(2-naphthylmethoxy- methyl)isoxazole-3-carboxylate

Nicholas R. Natale, Monica I. Szabon-Watola, Brendan Twamley, Richard J. Bridges, Sarjubhai Patel, Trideep Rajale

Research output: Contribution to journalArticlepeer-review

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The title compound, C26H23N5O8, was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004). Neuropharmacology, 46, 273-284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra-molecular N - H⋯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.

Original languageEnglish
Pages (from-to)o144-o145
JournalActa Crystallographica Section E: Structure Reports Online
Issue number1
StatePublished - 2008


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