TY - JOUR
T1 - Fat distribution and glucose metabolism in older, obese men and women
AU - Yeo, Sophie E.
AU - Hays, Nicholas P.
AU - Dennis, Richard A.
AU - Kortebein, Patrick M.
AU - Sullivan, Dennis H.
AU - Evans, William J.
AU - Coker, Robert H.
PY - 2007/12
Y1 - 2007/12
N2 - Background. Previous studies have identified relationships between subcutaneous abdominal fat (SAF), visceral fat (VF), and insulin resistance. In addition, lower muscle attenuation and decreased adiponectin have also been associated with insulin resistance. Methods. In order to define these relationships within a group of older, obese adults, we studied 48 individuals (20 men; 71 ± 1 years and 28 women; 65 ± 1 years) who underwent a single, hyperinsulinemic, euglycemic clamp procedure, computed tomography scan at the L4-L5 level, and whole-body plethysmography or dual energy x-ray absorptiometry. Endogenous glucose production (basal glucose Ra) was also measured at baseline and during the clamp procedure using an infusion of [6,62H2] glucose. Results. Mean body mass index (BMI; 31 ± 1 kg/m2) and glycosylated hemoglobin A1c (HbA1c; 5.7 ± 0.1%) levels were not significantly different between men and women. In men, there was an inverse relationship between SAF and insulin-stimulated glucose disposal (ISGD) (r = -.60, p = .01). In addition, there was a trend between thigh muscle attenuation and ISGD in men (r = .41, ñ = .07). Adiponectin was associated with ISGD in men (r = .46, p = .04) and women (r = .48, p = .01). There were no significant relationships between body fat distribution and basal glucose Ra in men or women, and no relationships between triglycerides and glucose metabolism. Conclusions. Our results indicate that (i) SAF was negatively associated with ISGD in men, (ii) thigh muscle attenuation demonstrated a trend toward ISGD in men, and (iii) adiponectin was associated with ISGD in men and women.
AB - Background. Previous studies have identified relationships between subcutaneous abdominal fat (SAF), visceral fat (VF), and insulin resistance. In addition, lower muscle attenuation and decreased adiponectin have also been associated with insulin resistance. Methods. In order to define these relationships within a group of older, obese adults, we studied 48 individuals (20 men; 71 ± 1 years and 28 women; 65 ± 1 years) who underwent a single, hyperinsulinemic, euglycemic clamp procedure, computed tomography scan at the L4-L5 level, and whole-body plethysmography or dual energy x-ray absorptiometry. Endogenous glucose production (basal glucose Ra) was also measured at baseline and during the clamp procedure using an infusion of [6,62H2] glucose. Results. Mean body mass index (BMI; 31 ± 1 kg/m2) and glycosylated hemoglobin A1c (HbA1c; 5.7 ± 0.1%) levels were not significantly different between men and women. In men, there was an inverse relationship between SAF and insulin-stimulated glucose disposal (ISGD) (r = -.60, p = .01). In addition, there was a trend between thigh muscle attenuation and ISGD in men (r = .41, ñ = .07). Adiponectin was associated with ISGD in men (r = .46, p = .04) and women (r = .48, p = .01). There were no significant relationships between body fat distribution and basal glucose Ra in men or women, and no relationships between triglycerides and glucose metabolism. Conclusions. Our results indicate that (i) SAF was negatively associated with ISGD in men, (ii) thigh muscle attenuation demonstrated a trend toward ISGD in men, and (iii) adiponectin was associated with ISGD in men and women.
UR - https://www.scopus.com/pages/publications/38549143193
U2 - 10.1093/gerona/62.12.1393
DO - 10.1093/gerona/62.12.1393
M3 - Article
C2 - 18166691
AN - SCOPUS:38549143193
SN - 1079-5006
VL - 62
SP - 1393
EP - 1401
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 12
ER -