G proteins, effecters and GAPs: Structure and mechanism

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G proteins form a diverse family of regulatory GTPases which, in the GTP-bound state, bind to and activate downstream effecters. Structures of Ras homologs bound to effector domains have revealed mechanisms by which G proteins couple GTP binding to effector activation and achieve specificity. Complexes between structurally unrelated GTPase-activating proteins with complementary G proteins suggest common mechanisms by which GTP hydrolysis is stimulated via direct interactions with conformationally labile switch regions of the G protein.

Original languageEnglish
Pages (from-to)849-856
Number of pages8
JournalCurrent Opinion in Structural Biology
Issue number6
StatePublished - Dec 1997


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