@article{59f63960f90a48e6984a84b58dad77b8,
title = "Genetic history of an archaic hominin group from Denisova cave in Siberia",
abstract = "Using DNA extracted froma finger bone found in Denisova Cave in southern Siberia, wehave sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed4-6%of its genetic material to the genomes of present-day Melanesians.Wedesignate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch.Atooth found in Denisova Cave carries a mitochondrialgenome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.",
author = "David Reich and Green, {Richard E.} and Martin Kircher and Johannes Krause and Nick Patterson and Durand, {Eric Y.} and Bence Viola and Briggs, {Adrian W.} and Udo Stenzel and Johnson, {Philip L.F.} and Tomislav Maricic and Good, {Jeffrey M.} and Tomas Marques-Bonet and Can Alkan and Qiaomei Fu and Swapan Mallick and Heng Li and Matthias Meyer and Eichler, {Evan E.} and Mark Stoneking and Michael Richards and Sahra Talamo and Shunkov, {Michael V.} and Derevianko, {Anatoli P.} and Hublin, {Jean Jacques} and Janet Kelso and Montgomery Slatkin and Svante P{\"a}{\"a}bo",
note = "Funding Information: Acknowledgements We thank C. Bustamante, A. I. Krivoshapkin, M. Lachmann, R. Nielsen, K. Pruefer, A. Tsybankov, L. Vigilant and W. Zhai for comments; K. Finstermeier for graphics work; the MPI-EVA sequencing group, R. Schultz and S. Weihnachtsmann for technical support; and P. Fujita, A. Hinrichs and K. Learned for designing the UCSC genome browser portal to the Denisova data. The Presidential Innovation Fund of the Max Planck Society and the Krekeler Foundation provided financial support. M.S. was supported by a US National Institutes of Health grant (R01-GM40282). The National Science Foundation provided an International Postdoctoral Fellowship (OISE-0754461) to J.M.G., a Fellowship in Biological Informatics to P.L.F.J. and a HOMINID grant (1032255) to D.R.",
year = "2010",
month = dec,
day = "23",
doi = "10.1038/nature09710",
language = "English",
volume = "468",
pages = "1053--1060",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Research",
number = "7327",
}