Genetic probes of ribosomal RNA function.

M. O'Connor, C. A. Brunelli, M. A. Firpo, S. T. Gregory, K. R. Lieberman, J. S. Lodmell, H. Moine, D. I. Van Ryk, A. E. Dahlberg

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


We have used a genetic approach to uncover the functional roles of rRNA in protein synthesis. Mutations were constructed in a cloned rrn operon by site-directed mutagenesis or isolated by genetic selections following random mutagenesis. We have identified mutations that affect each step in the process of translation. The data are consistent with the results of biochemical and phylogenetic analyses but, in addition, have provided novel information on regions of rRNA not previously investigated.

Original languageEnglish
Pages (from-to)859-868
Number of pages10
JournalBiochemistry and Cell Biology
Issue number11-12
StatePublished - 1995


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